Myocardial contractile function during ischemia and hypoxia.
نویسندگان
چکیده
منابع مشابه
Brief Review Myocardial Contractile Function During Ischemia and Hypoxia
Introduction Scope of Review Myocardial ischemia is one of the most common causes of serious illness and early death in developed societies. Furthermore, a variety of surgical procedures necessitate limited periods of ischemia. The reduced blood flow, which characterizes ischemia, deprives the heart of substrates and allows metabolites to accumulate. These changes lead to decreased tension prod...
متن کاملIntermittent hypobaric hypoxia improves postischemic recovery of myocardial contractile function via redox signaling during early reperfusion.
Intermittent hypobaric hypoxia (IHH) protects hearts against ischemia-reperfusion (I/R) injury, but the underlying mechanisms are far from clear. ROS are paradoxically regarded as a major cause of myocardial I/R injury and a trigger of cardioprotection. In the present study, we investigated whether the ROS generated during early reperfusion contribute to IHH-induced cardioprotection. Using isol...
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Placental growth factor (PlGF) has a distinct biological phenotype with a predominant proangiogenic role in disease without affecting quiescent vessels in healthy organs. We tested whether systemic administration of recombinant human (rh)PlGF improves regional myocardial blood flow (MBF) and systolic function recovery in a porcine chronic myocardial ischemia model. We implanted a flow-limiting ...
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RATIONALE Perioperative myocardial ischemia is common in high-risk patients. The use of interventional revascularisation or even thrombolysis is limited in this patient subset due to exceedingly high bleeding risks. Blockade of voltage-gated sodium channels (VGSC) with lidocaine had been suggested to reduce infarct size and cardiomyocyte cell death in ischemia/reperfusion models. However, the i...
متن کاملDissociation between epicardial and transmural function during acute myocardial ischemia.
The relationship between epicardial and transmural function (measured with sonomicrometers) was examined in 13 anesthetized open-chest dogs. Systolic wall thickening was used as a standard of integrated transmural function to compare with epicardial function measured as segment shortening parallel to surface fibers. Three levels of coronary inflow restriction were produced by using decrements i...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1987
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.60.2.153